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T
8 几个月前

I recently came across Calidi biotherapeutics and ...

I recently came across Calidi biotherapeutics and I am impressed by their commitment to advancing biotherapeutics. Their website is easy to navigate and provides comprehensive information about their products. The team is responsive and their dedication is evident. Keep up the good work!

N
1年以前

Calidi biotherapeutics is an excellent company. I ...

Calidi biotherapeutics is an excellent company. I have been following their work for several years and I am always impressed by their dedication to developing innovative treatments. Their website, calidibio.com, is easy to navigate and provides a wealth of information about their products and services. The team at Calidi is highly knowledgeable and always willing to answer any questions I have. I highly recommend Calidi biotherapeutics to anyone looking for cutting-edge biotherapeutics solutions.

J
1年以前

🔬 Calidi biotherapeutics is making great strides i...

🔬 Calidi biotherapeutics is making great strides in the field of biotherapeutics. Their website is user-friendly and provides comprehensive information about their revolutionary treatments. I appreciate their commitment to advancing healthcare. Keep it up! 👍

T
1年以前

🌟 Calidi biotherapeutics is doing an incredible jo...

🌟 Calidi biotherapeutics is doing an incredible job in the field of biotherapeutics. The information on their website is well-presented and their dedication to developing advanced treatments is commendable. I highly recommend Calidi to anyone seeking cutting-edge biotherapeutic solutions. 🙌

J
1年以前

I recently discovered a biotherapeutics company th...

I recently discovered a biotherapeutics company that has impressed me with their dedication to innovation. Their website is easy to navigate and the information provided is detailed and concise. I appreciate the effort that is put into ensuring patient safety and well-being. Way to go, Calidi!

E
1年以前

I have been a customer of Calidi biotherapeutics f...

I have been a customer of Calidi biotherapeutics for a while now and I must say they have exceeded my expectations. Their website, calidibio.com, provides all the necessary information about their cutting-edge biotherapeutics solutions. The team is responsive and the products are of the highest quality. I highly recommend Calidi to anyone in need of advanced biotherapeutics.

L
1年以前

👍 Calidi biotherapeutics is doing an amazing job i...

👍 Calidi biotherapeutics is doing an amazing job in the field of biotherapeutics. Their website, calidibio.com, is informative and easy to navigate. I appreciate their efforts in developing advanced treatments for various diseases. Keep up the good work! 👏

W
1年以前

I recently came across a biotherapeutics company t...

I recently came across a biotherapeutics company that caught my attention. Their website, calidibio.com, offers a user-friendly interface and detailed information about their groundbreaking treatments. I was particularly impressed by their commitment to ensuring patient safety and efficacy. Keep up the great work, Calidi!

G
1年以前

I am impressed with the work done by Calidi biothe...

I am impressed with the work done by Calidi biotherapeutics. Their website provides detailed information about their biotherapeutics solutions and their commitment to patient care. The team is knowledgeable and responsive. I am happy to be a customer of Calidi!

关于Calidi biotherapeutics

Calidi Biotherapeutics:用溶瘤病毒彻底改变癌症治疗

癌症是困扰人类几个世纪的最致命的疾病之一。尽管医学科学取得了重大进步,但癌症对研究人员和临床医生来说仍然是一个艰巨的挑战。然而,由于像 Calidi Biotherapeutics 这样致力于寻找癌症治疗方法的公司,希望就在眼前。

Calidi Biotherapeutics 是一家生物技术公司,专门开发溶瘤病毒 (OV) 作为治疗癌症的新方法。 OV 是一种病毒,可以选择性地感染和杀死癌细胞,同时保留健康细胞。这使它们成为传统化学疗法和放射疗法的有吸引力的替代方法,传统化学疗法和放射疗法由于其非特异性毒性而可能导致严重的副作用。

Calidi Biotherapeutics 的使命简单而雄心勃勃:通过提供旨在攻击癌症的 OV 来找到治愈癌症的方法。该公司的方法涉及使用经过基因改造的病毒,这些病毒被设计为根据其独特的分子特征靶向特定类型的癌细胞。

OV 的主要优势之一是它们能够刺激针对肿瘤的免疫反应。当 OV 感染癌细胞时,它们会触发免疫反应,帮助身体识别和攻击全身的其他肿瘤细胞。这使得它们对已经扩散到原位以外的转移性癌症特别有效。

Calidi Biotherapeutics 开发了几个专有的 OV 平台,基于不同类型的病毒,如腺病毒、单纯疱疹病毒(HSV)和牛痘病毒。每个平台都有自己独特的特性和功能,使它们能够以不同程度的特异性针对不同类型的癌症。

例如,卡力迪的先导候选产品CB-10-01基于腺病毒平台,在针对乳腺癌、肺癌、胰腺癌和黑色素瘤等多种实体瘤的临床前研究中取得了可喜的成果。 CB-10-01 的作用是靶向一种称为 CD46 的蛋白质,这种蛋白质在许多类型的癌症中过度表达,但在正常组织中没有。

Calidi Biotherapeutics 正在开发的另一个候选产品是基于 HSV 平台的 CB-11-01,该平台针对多形性胶质母细胞瘤 (GBM),这是一种最具侵袭性的脑肿瘤,尽管目前采用手术等标准治疗,但预后非常差随后进行放疗或化疗,或两者结合在一起。 GBM 经常在初始治疗后复发,因为其高度侵入性使得外科医生难以在手术期间切除所有肿瘤组织,导致在初始治疗后数月内复发。 CB-11-01 的作用是靶向另一种名为 nectin 1 的蛋白质,该蛋白质在 GBM 中高水平表达,但在正常脑组织中不表达。

除了开发新的 OV 疗法外,Calidi 还为寻求开发基于 OV 的产品的其他公司提供合同制造服务。公司位于加利福尼亚州圣地亚哥的最先进设施提供从工艺开发到临床试验材料生产的符合 cGMP 的制造服务。

总的来说,Calidi 生物疗法代表了肿瘤学研究中一个充满希望的新前沿,为曾经只有绝望的人们带来了希望。凭借其使用专门针对恶性细胞而设计的转基因病毒的创新方法,同时保持健康细胞完好无损,该公司可能有助于在对抗这种致命疾病的斗争中取得重大突破。

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Calidi biotherapeutics

Calidi biotherapeutics

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