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Disc Medicine：通过创新疗法革新贫血治疗
Disc Medicine 是一家生物技术公司，致力于为患有遗传性和获得性贫血的患者开发创新疗法。该公司的使命是恢复 hepcidin 的调节，它是遗传学和红细胞生成之间的联系，以创造新的治疗方法来改善全世界数百万人的生活。
贫血是一种常见的血液疾病，影响着全世界数百万人。当体内没有足够的红细胞或这些细胞不能正常工作时，就会发生这种情况。这会导致疲劳、虚弱、呼吸急促和其他严重影响一个人生活质量的症状。
目前对贫血的治疗是有限的，而且往往无效。许多患者需要频繁输血或补铁，这既费钱又费时。此外，这些治疗没有解决贫血的根本原因。
Disc Medicine 旨在通过开发针对铁调素调节的新疗法来改变这一现状。铁调素是一种由肝脏产生的激素，可调节体内铁的吸收。当铁调素水平低时，铁的吸收增加，导致肝脏和心脏等组织中铁的过量积累。随着时间的推移，这可能会造成损害，并导致血色素沉着症等疾病。
另一方面，当铁调素水平高时，铁吸收减少，由于红细胞生成（红细胞生成）所需的铁供应不足，导致贫血。 Disc Medicine 的方法侧重于通过针对参与其合成或降解途径的关键蛋白质的小分子药物来恢复适当的铁调素调节。
该公司基于这种方法开发了几种有前途的候选药物。其中包括 DM-1919（一种血幼素激动剂）、DM-3001（一种 TMPRSS6 抑制剂）和 DM-4004（一种铁调素模拟物）。这些药物在临床前研究中显示出可喜的结果，证明了它们改善贫血治疗的潜力。
Disc Medicine 的创新方法吸引了投资者和合作者的一致关注。迄今为止，该公司已筹集了超过 9000 万美元的资金，包括最近由 Novo Holdings 牵头的 5000 万美元 A 轮融资。此外，Disc Medicine 还与哈佛医学院和加州大学旧金山分校等领先学术机构建立了合作伙伴关系。
公司的领导团队由经验丰富的行业专业人士组成，他们拥有成功的记录。首席执行官 John Quisel 在生物技术和制药领域拥有超过 25 年的经验，在 ArQule Inc. 被默克公司收购之前曾担任首席执行官。其他主要成员包括首席科学官 Tomas Ganz 博士（著名的铁代谢专家）和首席医疗官 David Beeler 博士（Acceleron Pharma 前副总裁）。
总之，Disc Medicine 是一家生物技术公司，通过针对铁调素调节的创新疗法彻底改变贫血治疗。凭借正在开发的有前途的候选药物和来自投资者的强大资金支持，该公司处于有利地位，可以对全球数百万患有遗传性或获得性贫血的患者的生活产生重大影响。
discmedicine.com
