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P
8 几个月前

Kartos Therapeutics is an outstanding company in t...

Kartos Therapeutics is an outstanding company in the biotech industry. Their dedication to advancing healthcare through innovative drug development is commendable. The website offers a wealth of information, and their team's expertise is evident. Keep up the excellent work!

T
9 几个月前

I've had the pleasure of discovering Kartos Therap...

I've had the pleasure of discovering Kartos Therapeutics' website recently, and let me tell you, it's a goldmine of knowledge! The information presented is clear, concise, and easily accessible. Their dedication to improving healthcare through innovative drug development is truly inspiring.

D
10 几个月前

I stumbled upon a biotech company that fascinated ...

I stumbled upon a biotech company that fascinated me. The company's website, despite lacking the company's name, had a sleek and modern design. The information provided was concise and easy to understand. However, I would have appreciated additional details regarding their research goals.

A
11 几个月前

😊 Kartos Therapeutics is doing an amazing job in t...

😊 Kartos Therapeutics is doing an amazing job in the field of biotech. Their website provides comprehensive information that helps demystify the science behind their groundbreaking research. I am really impressed with their dedication and expertise. Keep up the good work! 👌

F
1年以前

👍 I visited Kartos Therapeutics' website and found...

👍 I visited Kartos Therapeutics' website and found their products intriguing. The descriptions were informative and helpful. However, I would have liked to see more detailed explanations about the underlying science. Overall, it was a decent experience.

N
1年以前

I've been following Kartos Therapeutics for some t...

I've been following Kartos Therapeutics for some time now, and I must say they never cease to amaze me. Their commitment to innovation and passion for improving lives is truly admirable. The website is informative and user-friendly, providing valuable insights into their groundbreaking work. Highly recommend!

S
1年以前

I recently discovered this amazing biotech firm th...

I recently discovered this amazing biotech firm through a friend. I was really impressed with their innovative approach and cutting-edge technologies. The quality of their work is outstanding, and their team is incredibly knowledgeable. I'm glad to have found Kartos Therapeutics, they are truly a game-changer!

R
1年以前

I had a really positive experience with Kartos The...

I had a really positive experience with Kartos Therapeutics. Their website is user-friendly and easy to navigate. The information provided about their products and services is clear and comprehensive. The customer support team was helpful and responsive to my inquiries. Overall, I highly recommend Kartos Therapeutics!

S
1年以前

Kartos Therapeutics has exceeded my expectations i...

Kartos Therapeutics has exceeded my expectations in terms of their dedication to scientific advancement in the biotech field. Their website offers a comprehensive overview of their work, and their team's expertise is evident in their achievements. Truly impressive!

B
1年以前

I came across a biotech company that caught my int...

I came across a biotech company that caught my interest. The website was user-friendly, and their products seemed promising. However, I felt that the information provided lacked depth and could've been more detailed. Overall, a decent experience, but room for improvement.

D
1年以前

👍 Kartos Therapeutics is a company that impressed ...

👍 Kartos Therapeutics is a company that impressed me right from the start. The website was easy to navigate, and their research focus really caught my attention. The team's expertise is evident, and I'm confident in their ability to make a positive impact in the biotech industry.

关于Kartos therapeutics

Kartos Therapeutics:用创新的 MDM2 抑制剂革新癌症治疗

Kartos Therapeutics 是一家临床阶段的生物制药公司,致力于开发创新的癌症治疗方法。该公司的主要重点是开发一种研究性 MDM2 抑制剂 navtemadlin (KRT-232),该药物在临床前和临床研究中显示出令人鼓舞的结果。

MDM2(小鼠双分钟 2 同系物)是一种蛋白质,在调节肿瘤抑制基因 p53 的活性方面起着关键作用。在正常细胞中,p53 通过在发生 DNA 损伤时诱导细胞周期停滞或细胞凋亡(程序性细胞死亡)来帮助防止肿瘤的形成和生长。然而,在许多类型的癌症中,p53 的功能由于突变或其他破坏其活性的改变而受损。

MDM2 抑制剂旨在通过阻断 p53 与 MDM2 的相互作用并促进其激活来恢复 p53 的功能。这种方法已被证明在各种类型癌症的临床前模型和早期临床试验中是有效的。

Navtemadlin (KRT-232) 是 Kartos 的主要候选产品,也是一种可口服的 MDM2 小分子抑制剂。它已在临床前模型中证明对几种类型的实体瘤和血液恶性肿瘤具有有效的抗肿瘤活性,包括急性髓系白血病 (AML)、骨髓增生异常综合征 (MDS)、淋巴瘤和多发性骨髓瘤。

在迄今为止进行的 1/2a 期临床试验中,navtemadlin 显示出令人鼓舞的安全性以及在多种肿瘤类型中令人鼓舞的疗效信号。正在进行的 1b/2 期研究旨在评估 navtemadlin 作为单药治疗或与其他药物联合治疗标准治疗失败的复发/难治性 AML 或高危 MDS 患者的安全性和有效性。

除了 navtemadlin 之外,Kartos 还拥有一系列针对癌症生物学不同方面的其他新型化合物,例如正在开发的 DNA 损伤反应途径,这些途径可能在未来单独使用或与现有疗法结合使用。

Kartos Therapeutics 的团队由经验丰富的科学家和临床医生组成,他们热衷于为癌症患者推进新疗法。他们密切合作,根据对疾病机制的前沿研究见解,确定药物开发的新目标。

总之,Kartos Therapeutics 为寻求支持使用 navtemadlin(KRT-232)等新型药物治疗癌症的创新方法的投资者提供了一个令人兴奋的机会。凭借他们强大的科学专业知识以及他们通过严格的研究努力改善患者结果的承诺 - 难怪为什么他们迅速成为该领域的顶级竞争者之一!

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Kartos therapeutics

Kartos therapeutics

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