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J
7 几个月前

👍I had an amazing experience with Mitobridge, inc....

👍I had an amazing experience with Mitobridge, inc.! The team was extremely professional and efficient in handling my requirements. They provided exceptional support throughout the entire process and delivered an outstanding result. I highly recommend their services.🌟

M
8 几个月前

I recently discovered a company that truly underst...

I recently discovered a company that truly understands the potential of mitochondrial medicine. Their approach is innovative, and their dedication to advancing research in this field is evident in their work. The website provides valuable insights into their scientific expertise and commitment to developing transformative therapies. The user-friendly interface and clear navigation make it easy to explore their discoveries. 🧬 I was impressed by their mission to address diseases at the root of their origin, and their focus on bringing hope to patients living with mitochondrial disorders. The company’s dedication to advancing mitochondrial research is commendable, and their contributions are paving the way for groundbreaking treatments. I am excited to see the impact of their work in the field of mitochondrial medicine.

P
9 几个月前

I recently availed services from a company and I'm...

I recently availed services from a company and I'm extremely satisfied with the outcome. The team provided excellent support throughout the process and delivered exceptional results. I highly recommend their services to anyone in need. Keep up the good work!

M
10 几个月前

Mitobridge, inc. has exceeded my expectations in e...

Mitobridge, inc. has exceeded my expectations in every way. Their attention to detail and commitment to customer satisfaction is truly commendable. I am thoroughly impressed with their exceptional service and professionalism. They have earned my highest recommendation.

J
1年以前

Mitobridge, inc. is an exceptional company that tr...

Mitobridge, inc. is an exceptional company that truly cares about their customers. The team was attentive, knowledgeable, and went the extra mile to ensure my complete satisfaction. I highly recommend their services.🌟

S
1年以前

I received outstanding service from a company rece...

I received outstanding service from a company recently. The team at Mitobridge, inc. was highly professional and responsive, ensuring that all my needs were met. I'm extremely impressed and would recommend their services to anyone in need. Keep up the good work!

Z
1年以前

I recently used a company for my needs and it was ...

I recently used a company for my needs and it was a great experience. The team at Mitobridge, inc. provided top-notch service without any hiccups. I was happy with the overall outcome and would definitely recommend their services to others. Keep up the good work!

A
1年以前

👍I had a fantastic experience with Mitobridge, inc...

👍I had a fantastic experience with Mitobridge, inc.! The team was highly professional and responsive. They went above and beyond to meet my requirements and provided exemplary service. I'm extremely pleased with the outcome.

M
1年以前

Mitobridge, inc. is a company that truly understan...

Mitobridge, inc. is a company that truly understands the needs of their customers. I am impressed with their exceptional customer service and attention to detail. The team went above and beyond to ensure that all my concerns were addressed promptly. Their dedication to excellence is evident in every interaction I had with them. I highly recommend Mitobridge, inc.

A
1年以前

I recently had the pleasure of working with a rema...

I recently had the pleasure of working with a remarkable company. The team at Mitobridge, inc. provided exceptional service, addressing all my concerns in a timely manner. I'm extremely satisfied with the outcome and would highly recommend their services.

关于Mitobridge, inc.

Mitobridge, Inc. - 发现和开发新型小分子疗法以改善线粒体功能

Mitobridge, Inc. 是一家生物制药公司,致力于发现和开发可改善线粒体功能的新型小分子疗法。该公司由一群经验丰富的科学家于 2011 年创立,他们认识到靶向线粒体作为治疗各种疾病的一种方式的潜力。

线粒体是存在于身体每个细胞中的细胞器,负责通过氧化磷酸化产生能量。它们在细胞代谢中起着至关重要的作用,并参与许多重要的生理过程,例如细胞凋亡、钙信号传导和活性氧 (ROS) 的产生。

然而,线粒体功能障碍与许多疾病有关,包括阿尔茨海默病和帕金森病等神经退行性疾病、糖尿病和肥胖症等代谢紊乱、心力衰竭和中风等心血管疾病以及癌症。

Mitobridge 的使命是开发针对线粒体功能障碍的创新疗法,以改善患者的预后。该公司开发了一种名为 Mitoguard™ 的专有平台技术,可以识别可调节线粒体功能的小分子。

Mitoguard™ 平台将高通量筛选与先进的计算方法相结合,以识别可选择性靶向线粒体功能特定方面的化合物。与传统方法相比,这种方法可以发现具有更高疗效和安全性的新型候选药物。

Mitobridge 创新方法的一个例子是他们的先导化合物 MA-0211,它靶向 PGC-1α(过氧化物酶体增殖物激活受体 γ 共激活因子 1-alpha),一种线粒体生物发生的关键调节剂。 MA-0211 在通过增加能量产生改善心脏功能来治疗心力衰竭的临床前研究中显示出可喜的结果。

除了 MA-0211,Mitobridge 还有其他几个项目专注于开发针对各种适应症的疗法,包括神经退行性疾病,如亨廷顿舞蹈病和 ALS(肌萎缩侧索硬化)、代谢紊乱,如非酒精性脂肪性肝炎(NASH)和 2 型糖尿病(T2DM) )、肺动脉高压 (PAH) 和缺血再灌注损伤 (IRI) 等心血管疾病,以及急性髓性白血病 (AML) 等肿瘤适应症。

公司已与领先的制药公司建立了合作伙伴关系,包括安斯泰来制药公司、武田制药有限公司、艾伯维公司、杨森制药公司等,为研究活动提供资金支持,同时提供药物开发方面的专业知识。

总之,Mitobridge 是一家创新型生物制药公司,专注于发现可改善多个治疗领域线粒体功能的新型小分子疗法。凭借其专有平台技术 Mitoguard ™与行业内强大的合作伙伴关系,它旨在为患有线粒体功能障碍引起的虚弱状况的患者提供新的治疗选择,同时通过成功的商业化努力为其股东创造价值。

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Mitobridge, inc.

Mitobridge, inc.

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