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Nabriva Therapeutics Plc：彻底改变与严重感染的斗争
在当今世界，抗生素耐药性正成为一个主要问题，Nabriva Therapeutics Plc 是希望的灯塔。这家处于商业阶段的生物制药公司致力于开发治疗严重感染的新型抗生素。 Nabriva 目前专注于截短侧耳素类抗生素，旨在彻底改变我们对抗传染病的方式。
Nabriva 成立于 2006 年，总部位于爱尔兰都柏林，自成立以来已经取得了长足的进步。公司的使命是解决因多重耐药菌引起的严重感染患者未满足的医疗需求。 Nabriva 拥有一支经验丰富的科学家和研究人员团队，在开发能够对抗这些致命病原体的创新解决方案方面取得了重大进展。
Pleuromutilin 类抗生素：游戏规则改变者
Nabriva 的主要重点是开发截短侧耳素类抗生素。这些是天然存在的化合物，已在兽医学中使用了几十年，但直到最近才被探索用于人类的潜在用途。
截短侧耳素通过抑制细菌蛋白质合成和破坏细胞壁形成发挥作用。这使得它们对多种革兰氏阳性菌有效，例如金黄色葡萄球菌（包括 MRSA）、肺炎链球菌（包括耐药菌株）和屎肠球菌（包括万古霉素耐药菌株）。
Nabriva 在该类别中最有前途的药物之一是 lefamulin (Xenleta®)。 Lefamulin 于 2019 年 8 月获得 FDA 批准用于治疗成人社区获得性细菌性肺炎（CABP）。它通过口服或静脉内给药，对常见的呼吸道病原体（如肺炎链球菌和流感嗜血杆菌）显示出极佳的疗效。
与用于治疗 CABP 的现有抗生素相比，Lefamulin 具有多项优势。它具有独特的作用机制，可降低与其他类别抗生素交叉耐药的风险。它还具有出色的组织渗透特性，使其能够在发生感染的部位达到高浓度。
除了 lefamulin 之外，Nabriva 还开发了其他几种来自截短侧耳素类的药物，这些药物针对不同类型的感染，例如由革兰氏阳性菌引起的皮肤和软组织感染 (SSTI)。
对患者安全的承诺
在 Nabriva Therapeutics Plc.，患者安全是第一位的。该公司在对其药物进行临床试验时遵循 FDA 和 EMA 等监管机构制定的严格指导方针。
在开始人体临床试验之前，Nabriva 会进行广泛的临床前研究，以确保在人体试验开始之前充分了解安全性和有效性概况。所有临床试验均根据全球监管机构制定的良好临床实践指南进行。
该公司还与世界各地领先的学术机构合作，这些机构共同致力于通过旨在发现由多重耐药细菌引起的传染病的新疗法的创新研究计划来改善患者的治疗效果。
结论
总之，Nabriva Therapeutics Plc 代表了我们抗击由多重耐药细菌引起的严重感染的激动人心的新篇章。它专注于从截短侧耳素类中开发新型抗生素，为患有由革兰氏阳性菌引起的 CABP 或 SSTI 等危及生命的疾病的患者带来了希望。
从他们迄今为止的记录可以看出——包括 FDA 对 lefamulin 的批准——他们已经在实现这一目标方面取得了重大进展，同时在药物开发过程涉及的所有阶段都严格遵守患者安全标准；让他们值得关注！
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