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Sengenics：彻底改变自身抗体生物标志物的发现
Sengenics 是一家领先的生物技术公司，专门开发行业首创的血清学技术。该公司独特的能力彻底改变了临床相关自身抗体生物标志物的发现，这些生物标志物对于诊断和治疗各种疾病至关重要。
Sengenics 总部位于新加坡，已成为血清学领域的全球领导者。该公司的尖端技术已被世界各地的研究人员和临床医生用于识别自身免疫性疾病、癌症、传染病和其他疾病的新型生物标志物。
Sengenics 与其他生物技术公司的不同之处在于它对蛋白质阵列的关注。与依赖 DNA 或 RNA 测序来识别生物标志物的传统方法不同，Sengenics 使用蛋白质阵列直接检测自身抗体。这种方法提供了优于传统方法的几个优点。
首先，蛋白质阵列允许同时对数千种蛋白质进行高通量筛选。这意味着研究人员可以快速识别潜在的生物标志物，而无需单独测试每一个。其次，蛋白质阵列具有高灵敏度和特异性，这意味着它们可以高精度地检测甚至低水平的自身抗体。
Sengenics 的旗舰技术称为 KREX（Killer-REx），代表“Killer-Exonuclease”。 KREX 是一个获得专利的平台，可以生产具有天然构象的全长重组蛋白。这项技术使研究人员能够同时筛选大量蛋白质，同时保持其天然结构和功能。
Sengenics 开发的另一项关键技术称为 ImmuSAFE（通过荧光发射进行免疫球蛋白特征评估）。 ImmuSAFE 是一种使用荧光标记抗原检测自身抗体的专有方法。该技术使研究人员能够实时可视化抗体和抗原之间的结合模式。
Sengenics 的技术已用于众多研究和临床试验。例如，该公司与牛津大学的研究人员合作，确定多发性硬化症 (MS) 的自身抗体生物标志物。该研究发表在 Nature Communications 上，确定了几种可用于诊断和监测 MS 的新型生物标志物。
Sengenics 还与几家制药公司合作，开发基于其血清学技术的新药。 2019年，公司宣布与武田药品工业株式会社合作发现和验证炎症性肠病（IBD）的自身抗体生物标志物。
除了研究合作外，Sengenics 还提供一系列服务来支持药物发现和开发。这些服务包括蛋白质表达和纯化、抗体生产、分析开发和生物信息学分析。
总的来说，Sengenics 是一家开创性的生物技术公司，它改变了血清学领域。其创新技术使全球研究人员能够加速发现各种疾病的临床相关自身抗体生物标志物。凭借对创新和协作的持续关注，Sengenics 有望在未来几年做出更大的贡献。
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