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The company's website is super user-friendly and engaging, with a wide range of innovative products to explore. Their customer service is top-notch, always prompt and helpful. Highly recommended!
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I recently made a purchase from this company and I am extremely satisfied with the products I received. The website was easy to use and the ordering process was smooth. The customer service team was responsive and answered all my questions promptly. I would definitely buy from them again!
Exonate Limited:革新年龄相关性黄斑变性的治疗
Exonate Limited 是一家生物制药公司,致力于开发针对年龄相关性黄斑变性 (AMD) 的创新疗法。该公司的主要重点是湿性 AMD,这是 50 岁以上人群失明的主要原因。Exonate 治疗湿性 AMD 的方法涉及靶向 VEGF 选择性剪接,这有可能彻底改变这种疾病的治疗方式。
什么是年龄相关性黄斑变性?
年龄相关性黄斑变性 (AMD) 是一种进行性眼病,影响着全世界数百万人。当负责中央视力的黄斑随时间恶化时,就会发生这种情况。 AMD 有两种类型:干性和湿性。干性 AMD 约占所有病例的 90%,并且随着时间的推移进展缓慢。另一方面,湿性 AMD 约占病例的 10%,但进展速度要快得多,如果不及时治疗可能会导致严重的视力丧失。
目前湿性 AMD 的标准治疗包括每隔几周或几个月将抗 VEGF 药物直接注射到眼睛中。虽然这些药物可以有效减缓甚至阻止湿性 AMD 的进展,但它们价格昂贵且需要频繁注射,这对患者来说可能会感到不舒服和不便。
Exonate 治疗湿性 AMD 的方法
Exonate Limited 认为,靶向 VEGF 可变剪接可能是治疗湿性 AMD 的更好方法。 VEGF(血管内皮生长因子)在血管生成(新血管的形成)中起重要作用,这是正常组织生长和修复所必需的。然而,在湿性 AMD 等情况下,视网膜中会发生异常血管生长,从而导致视力丧失。
通过使用其称为“ESG”的专有技术平台靶向 VEGF 选择性剪接,Exonate 旨在开发一类新型药物,该药物可以选择性地抑制与湿性 AMD 相关的异常血管生长,同时保持正常血管生成完好无损。这种方法有可能比目前的湿性 AMD 治疗更有效且侵入性更小。
Exonate 的管道
Exonate Limited 拥有强大的处于不同开发阶段的候选药物管道。该公司的主要候选药物 EXN407 是一种针对 VEGF 选择性剪接的小分子抑制剂。在临床前研究中,EXN407 在减少视网膜异常血管生长而不影响正常血管生成方面显示出可喜的结果。
除了 EXN407,Exonate 还在开发其他候选药物,这些候选药物使用其 ESG 平台靶向 VEGF 选择性剪接。这些包括:
- EXN408:与 EXN407 相比,第二代小分子抑制剂具有更高的效力和选择性。
- EXN409:一种基于肽的抑制剂,靶向 VEGF 选择性剪接。
- EXN410:一种靶向 VEGF 选择性剪接的反义寡核苷酸 (ASO) 抑制剂。
所有这些候选药物都在临床前研究中显示出可喜的结果,并有望很快进入临床试验。
Exonate 的合作伙伴关系
Exonate Limited 已与领先的制药公司和研究机构建立了多项战略合作伙伴关系,以推进其药物开发计划。这些伙伴关系包括:
- Janssen Pharmaceuticals:2019 年,Exonate 与 Janssen Pharmaceuticals(强生公司的子公司)达成合作协议,利用 Exonate 的 ESG 平台开发视网膜疾病的新疗法。
- 伦敦大学学院 (UCL):Exonate 与 UCL 眼科研究所持续合作,以推进其对 VEGF 选择性剪接及其在视网膜疾病中的作用的理解。
- Medicines Discovery Catapult:2020年,Exonate 获得了 Medicines Discovery Catapult 的资助,以支持开发其治疗湿性 AMD 的候选药物。
结论
Exonate Limited 是一家生物制药公司,致力于开发针对年龄相关性黄斑变性 (AMD) 的创新疗法,主要关注湿性 AMD。该公司的方法涉及针对 VEGF 可变剪接,这有可能比目前的湿性 AMD 治疗更有效且侵入性更小。凭借强大的候选药物管道以及与领先制药公司和研究机构的战略合作伙伴关系,Exonate 处于有利地位,可以彻底改变这种衰弱性疾病的治疗方法。